produced by 平野宏文　Hirofumi Hirano a neurosurgeon, to communicate with his patients and friends

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これまでの仕事

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論文2005年以降

  • The environment of increased concentration of docosahexaenoic acid in glioblastoma may suppress the anti-tumor effect of macrophages. Oncol Rep, 13 : 1185-1191, 2005
  • High incidence of microbleeds in hemodialysis patient detected by T2*-weighted gradient-echo magnetic resonance imaging. Neurol Med-Chir, 45(11) : 556-560, 2005
  • Disseminated intravascular coagulation complicating resection of a malignant meningioma. Brit J Neurosurg, 20(4) : 239-241, 2006
  • The functional alteration of mutant GFAP depends on the location of the domain, morphological and functional studies using astrocytoma-derived cells. J Hum Genet, 52 : 362-369, 2007
  • Treatment of elderly acromegalics. Endocr J, 55 : 895-903, 2008
    Changes in tissue factor and the effects of tissue factor pathway inhibitor on transient focal cerebral ischemia in rats. Thromb Res, 122 : 247-255, 2008
  • Consecutive histological changes in an astroblastoma that disseminated to the spinal cord after repeated intracranial recurrences, a case report. Brain Tumor Pathol, 25 : 25-31, 2008
  • Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor β. Cancer Immunol Immun, 58(10) : 1577-1586, 2009
  • Xanthogranuloma in the suprasellar region. Neurol Med-Chir, 49(3) : 124-127, 2009
    Relationship between cytokeratin staining patterns and clinico-pathological features in somatotropinomae. Eur J Endocrinol, 163, Issue 4 : 531-539, 2010
  • Aneurysm on the cortical branch (P4 segment) of the posterior cerebral artery.case report. Neurol Med-Chir, 50(12) : 1084-1087, 2010
  • Germinoma with syncytiotrophoblastic giant cells arising in the corpus callosum-case report-. Neurol Med-Chir, 50(7) : 588-591, 2010
  • Metastatic pineal tumors treated by neuroendoscopic surgery. Neurol Med-Chir, 50 : 232-236, 2010
  • Prolactin-producing pituitary adenoma with abundant spherical amyloid deposition masquerading as extensive calcification. Neurol Med-Chir, 50 : 1023-1026, 2010
  • Role of sonic hedgehog signaling in migration of cell lines established from CD133-positive malignant glioma cells. J Neuro-oncol, 104 : 697-704, 2011
  • Wnt-5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and MMP-2. Cancer Sci, 102(3) : 540-548, 2011
  • Identification of CD133+ Cells in Pituitary Adenomas. Neuroendocrinology, 94 : 302-312, 2011
  • Gradual declination of IGF-1 over a year after transsphenoidal adenomectomy of GH producing pituitary adenomas. Endocr J, 58(12) : 1087-1091, 2011
  • Pineal mixed germ cell tumor with a synchronous sellar lesion in the sixth decade. Brain tumor pathol, 28(2) : 163-166, 2011
  • Diffuse large B-cell lymphoma within a cavernous hemangiomaof the cavernous sinus. Brain Tumor Pathol, 28 (4) : 353-358, 2011
  • Cerebellopontine angle endodermal cyst presenting with hemifacial spasm, a case report. Brain Tumor Pathol, 28(4) : 371-374, 2011
  • Intracranial germinoma presenting with hemiatrophy- follow-up results and literature review-two case reports-. Neurol Med-Chir, 51(2) : 148-152, 2011
  • TLR4, IL-6, IL-18, MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6. Neuropathology, 32(6) : 628-637, 2012
  • Low distribution of synaptic vesicle protein 2A and synaptotagimin-1 in the cerebral cortex and hippocampus of spontaneously epileptic rats exhibiting both tonic convulsion and absence seizure. Neuroscience, 3 : 12-20, 2012
  • MRI findings in patients with central neurocytomas with special reference to differential diagnosis from other ventricular tumours near the foramen of Monro. J Clin Neurosci, 19(5) : 681-686, 2012
  • Primary malignant melanoma in the pineal region treated without chemotherapy. Surgical Neurology International : DOI:10.4103/2152-7806.102348, 2012
  • Severe growth hormone deficiency is rare in surgically-cured acromegalics. Pituitary, 16(3) : 326-332, 2013
  • MRI T2 hypointensity of metastatic brain tumors from gastric and colonic cancers. Int J Clin Oncol, 19(4) : 643-648, 2013
  • Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma. Oncotarget, 4(12) : 2261-2270, 2013
  • Entry point to the Sylvian fissure for the pterional transsylvian approach. Cent Eur Neurosurg, 74(4) : 228-233, 2013
  • Immunohistochemical expression of thrombomodulin in vestibular schwannoma. Brain Tumor Pathol, 30(1) : 28-33, 2013
  • Mature posterior fossa teratoma mimicking dermoid cyst. Brain Tumor Pathol, 30(4) : 262-265, 2013
  • Geometric survey on magnetic resonance imaging of growth hormone producing pituitary adenoma. Pituitary, 17(2) : 142-149, 2014
  • A multicenter phase I/II study of the BCNU implant (Gliadel@ Wafer) for Japanese patients with malignant gliomas. Neurol Med-Chir, 54 : 290-301, 2014
  • Transsphenoidal surgical treatment of pituitary adenomas in patients aged 80 years or older. Neurosurg Rev, 37 : 269-277, 2014
  • Ryk is essential for Wnt-5a-dependent invasiveness in human glioma. J Biochem, 156(1) : 29-38, 2014
  • Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma. Neuroradiology, 56(7) : 525-534, 2014
  • Imaging discrepancies between magnetic resonance imaging and brain perfusion single-photon emission computed tomography in the diagnosis of Alzheimer’s disease, and verification with amyloid positron emission tomography. Psychogeriatrics, 14(2) : 110-117, 2014
  • Improvement in treatment results of glioblastoma over the last three decades and beneficial factors. Br J Neurosurg, 29(2) : 206-212, 2014
  • Third ventricular atypical meningioma which recurred with further malignant progression. Brain Tumor Pathol, 32(1) : 56-60, 2014
  • Menstrual restoration in severe panhypopituitarism many years after cranial irradiation for suprasellar germinoma. Reproductive Medicine and Biology : DOI : 10.1007/s12522-014-0200-6, 2014
  • Pituitary metastases: current practice in Japan. J Neurosurg, 123(4) : 998-1007, 2015
    New type of encephalomyelitis responsive to trimethoprim/sulfamethoxazole treatment in Japan. Neurol Neuroimmunol Neuroinflamm : DOI: 10.1212/NXI.0000000000000143, 2015
  • Choroid Plexus Tumors: Experience of 10 Cases with Special References to Adult Cases. Neurol Med Chir (Tokyo), 55(12) : 891-900, 2015
  • Intra-bronchial migration of peritoneal catheter of lumboperitoneal shunt. Surgical Neurology International, 6 : 167, 2015
  • A novel bilateral approach for suprasellar arachnoid cysts: a case report. Pediatric Neurosurgery, 51(1) : 30-34, 2015
  • Solitary cranial langerhans cell histiocytosis: two case reports. Hiroshima J. Med. Sci., 64(4) : 59-63, 2015
  • Treatable glomerular hyperfiltration in patients with active acromegaly. European Journal of Endocrinology, 175(4) : 325-333, 2016
  • Multicentric glioma develops via a mutant IDH1-independent pathway: immunohistochemical study of multicentric glioma. Pathobiology, 84(2) : 99-107, 2016
  • Efficacy of bevacizumab therapy for unresectable malignant glioma: A retrospective analysis. Molecular and Clinical Oncology, 6(1) : 105-110, 2016
  • Changes in quality of life in patients with acromegaly after surgical remission – A prospective study using SF-36 questionnaire. Endocrine Journal, 64(1) : 27-38 , 2016
  • ATP7B expression confers multidrug resistance through drug sequestration. Oncotarget , 7(16) : 22779-22790, 2016
  • Radiologic and histologic features of the T2 hyperintensity rim of meningiomas on magnetic resonance images. The Neuroradiology Journal, 30(1) : 48-56, 2016
  • Ganglioglioma in the third ventricle: a case report and literature review. NMC Case Report Journal : DOI: 10.2176/nmccrj.cr.2016-0038, 2016
  • Rapid malignant transformation of low-grade astrocytoma in a pregnant woman: Malignant transformation of astrocytoma. Journal of Obstetrics and Gynaecology Research, 42(10) : 1385-1389, 2016
  • Long-term outcomes of epilepsy surgery in 85 pediatric patients followed up for over 10 years: a retrospective survey. Journal of Neurosurgery Pediatrics, J Neurosurg Pediatr 3 : 1-10, 2017
  • Antitumor activity of gemcitabine against high-grade meningioma in vitro and in vivo. Oncotarget : DOI: 10.18632/oncotarget.18827, 2017
  • Preoperative and Postoperative Pituitary Function in Patients with Tuberculum Sellae Meningioma -based on pituitary provocation tests-. Neurol Med-Chir: DOI: 10.2176/nmc.oa.2017-0079, 2017
  • Anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: a case report. Molecular and Clinical Oncology : DOI: 10.3892/mco.2017.1160, 2017
  • Calcifying pseudoneoplasm of the neuraxis in direct continuity with a low-grade glioma: A case report and review of the literature. Neuropathology : DOI: 10.1111/neup.12384, 2017
  • Bilateral lateral ventricular subependymoma with extensive multiplicity presenting with hemorrhage. The Neuroradiology Journal : http://journals.sagepub.com/doi/pdf/10.1177/1971400917718843, 2017
  • Long-term outcome after endovascular treatment of cavernous sinus dural arteriovenous fistula and a literature review. Acta Neurochir, 159(11): 2113-2122, 2017
  • ATP7B expression in human glioblastoma is related to temozolomide resistance. Oncology Letters, 14: 7777-7782, 2017
  • JCOG0911 INTEGRA study: a randomized screening phase II trial of interferonβ plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma. Journal of Neuro-Oncology, 138: 627-636, 2018
  • Histogram analysis of amide proton transfer–weighted imaging: comparison of glioblastoma and solitary brain metastasis in enhancing tumors and peritumoral regions. European Radiology, 29(8): 4133-4140, 2018
  • A Clinical Rule for Preoperative Prediction of BRAF Mutation Status in Craniopharyngiomas. NEUROSURGERY, 85(2): 204-210, 2019
  • Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis. International Journal of Molecular Sciences, 20(24): 6355, 2019
  • Histogram analysis of amide proton transfer–weighted imaging:comparison of glioblastoma and solitary brain metastasis in enhancing tumors and peritumoral regions. Eur Radiol, 29(8): 4133-4140, 2019
  • High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme. British Journal of Cancer, 120: 819-826, 2019
  • Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma. Neuro-Oncology, 23(6): 945-954, 2021
  • Dural sac shrinkage signs on magnetic resonance imaging at the thoracic level in spontaneous intracranial hypotension—its clinical significance. Acta Neurochirurgica, 163(10): 2685-2694, 2021

Hirofumi Hirano MD, PhD, Department of Neurosurgery